Sunday, 14 October 2018

What will be the Future of Antimicrobials?

Bacterial resistant- This study may aid in preventing antibacterial resistance!!

Bacteria are microscopic single-celled organisms. It consists of a single cell with a simple internal structure. Most of the bacteria are harmless and beneficial. Only a few species are harmful and cause diseases. Antimicrobials are the agent that kills or prevent the growth of microorganisms such as bacteria, viruses or fungi. Nowadays bacteria are rapidly evolving and becoming resistant to these antimicrobials.

The new materials researchers have designed and built allow antibacterial to be more potent and have the ability to wipe out bacteria at smaller concentrations than the antibacterial can do on their own. Scientists have discovered a new drug delivery system that may help prevent bacterial infections.
The researchers synthesised nanostructured silica particles, considered to be promising drug carriers, that contained payloads of an antimicrobial agent.
According to the previous study, they found that the particles were effective at killing two human bacterial pathogens.
While antibiotics are taken orally and that they become extensively distributed throughout the body. But the new mechanism allows compounds to slowly release antimicrobials into local environments, resulting in high amounts of the molecule in a specific location.
Interestingly, the particles were more effective at killing the bacteria which may highlight a more efficient mechanism for drug delivery.
This is because the newly designed nanomaterials allow the antibacterial to be localised, released slowly and attack the microorganism more effectively
Researchers said the study could lead to the development of new microscopic particles containing drugs, antiseptics or pesticides that may increase the effectiveness of the therapy and aid in preventing antibacterial resistance

Friday, 5 October 2018

Is Turmeric GOOD or BAD?

This new research about turmeric will Surprise you!!

Turmeric is a flowering plant of the ginger family, Zingiberaceae. Curcumin is the active compound that found in turmeric which has effective biological properties. Turmeric has been used in Asia for thousands of years and is a major part of medicine.

Turmeric might be the foremost effective dietary supplement in presence. Turmeric milk that we were consuming for years have become a new discovery in the West as a. “superfood”

Medically speaking, turmeric has traditionally been used to enhance immunity, heal wounds and improve anti-oxidants in the body. Researches have proven that the right dosage of turmeric, consumed in any form can assist Alzheimer's disease, reduce coronary heart attacks and additionally enhance overall brain function.
For a healthy body, specialists and researchers recommend ingesting up to 500 mg of turmeric each day to hold better health. The dosage also can increase in case of serious illnesses.
A research proves that turmeric has healing properties when used both as a spice as well as medicine, it may not be really powerful because the body faces a difficult time ingesting it. If curcumin would not certainly make its way to the intestine and digestive system, it might as well be good for nothing.
Curcumin is the active compound found in turmeric when it enters into the bloodstream will not be absorbed easily that makes no benefit. Researchers conducted a study by observing a trail with a group of patients who utilized turmeric to treat their illness but found zero improvements.
By combining turmeric's anti-inflammatory properties with sugary drinks and may be quite toxic and fatal.

At the same time, researchers warned against eliminating turmeric from the diet. Curcumin may not get absorbed easily however it is an effective component with many uses. Specialists suggest the use of turmeric with black pepper because Black pepper contains a herbal compound which helps in its absorption. If no longer medicinal, specialist’s support that turmeric with all its holistic healing benefits would not do the body any kind of bad.

Saturday, 29 September 2018

Toxic Blooms

Researchers Reveal Genetic Basis for Toxic Algal Blooms

The algal bloom is a rapid increase or accumulation in the population of algae in freshwater or marine water systems and is recognized by the discolouration in the water from their pigments.
A Harmful Algal Bloom (HAB) is an algal bloom that reasons terrible effects to other organisms through the production of natural toxins, mechanical damage to different organisms, or by means of another manner.

In humans, the toxin can cause rashes, skin lesions, headaches and stomach pain.

Despite decades of research, the trigger that causes algal blooms to begin poisoning their environment has long confounded scientists.

Now, researchers have found the genetic underpinning of domoic acid, a harmful neurotoxin. In a newresearchers describe three genes responsible for producing domoic acid in the phytoplankton Pseudo-nitzschia.

Monitoring how the clusters of genes behave could one-day yield information on which environmental or biological triggers are responsible for activating them. That information could help fisheries and public health officials predict when harmful algal blooms will occur, allowing them to effectively prepare.

The "very small" cluster of genes responsible for the production of the toxin is a relatively rare phenomena compared to other similar organisms, indicating that they may serve some important biological function.

Researchers say "It's not there to make us sick. There are different theories for why it's there, including serving as a feeding deterrent,"
They speculate the toxin may deter organisms that would feed upon the algae.  Or it may be that the toxin allows algae to chemically bond to nutrients, such as iron, present in the water.
The discovery of these genes will allow us to explore many theories

Monday, 24 September 2018

Shaping the Future:

Computational Exploration and Design of Functional Compounds

Researchers work on the development of forefront computational methods at the interface of chemistry, biology, physics and materials science. Highly accurate approaches derived from quantum mechanics have been the focus of their research, as have applications of their methods which include a broad range of systems – from (bio-) molecules over functional co-ordination compounds, to condensed phase systems. In-depth study and informed in silico design are carried out to obtain systems with desired properties and functionalities. Examples include complex processes such as solar light-driven catalysis for sustainable hydrogen production as a promising solution to the world’s energy problem.

Theoretical and computational chemistry, biophysics, and materials science                 

Chirality plays a vital role in many aspects of chemistry, biology, and physics. Vibrational Raman optical activity spectroscopy enables valuable information on the structure and dynamics of systems and has been widely used to study molecules in solution. Based on a newly developed approach, it became possible to present the first spectra for chiral metal complexes and a large metalloprotein, thus opening up an exciting field of research for coordination compounds as well as the theoretical exploration of complex (bio-)molecules. The special case of Resonance Raman optical activity has also been further developed, which can provide important additional information due to resonance with electronically excited state(s).
Alongside static computational approaches, the group has presented a method for the first calculation of vibrational Raman optical activity spectra via forefront ab initio molecular dynamics, which includes effects such as anharmonicity and can treat systems at ambient environment.

Having been involved in the study of various compounds ranging from (bio-)molecules over liquids to molecules on surfaces, recent group projects in collaboration with other groups have also, for example, concerned the investigation of electronic communication in dirhenium complexes, photoinduced proton-coupled electron transfer, and the development of refinement procedures for improved agreement of computational models and experimental data.

Saturday, 15 September 2018

Join Your Hands for a Good Cause

World Congress on Bioorganic and Medicinal Chemistry scheduled on November 12-13, 2018 Dubai, UAE goes with the theme Explore the latest trends in Bioorganic and Medicinal Chemistry.
Bioorganic Medicinal 2018  is an international event focusing on the core knowledge and major advances in the ever-expanding field of Bioorganic and Medicinal Chemistry by attracting experts on a global scale. It is a global platform to discuss the innovative researches and developments in the Bioorganic and Medicinal Chemistry. It will be a golden opportunity to meet eminent personalities and to learn the latest technological advancements.

The distinctive features of the conference includes
·         Pharmaceutical Chemistry
·         Structural & Medicinal Biochemistry
·         Biological Drug Targets
·         Drug Design, Discovery and Development
·         Drug delivery Techniques
·         New Trends in Medicinal pharmacy
·         Global Chemical Analysis
·         Organic Chemistry in Today’s Life
·         Bioorganic and Medicinal Chemistry
·         Medicinal Chemistry
·         Pharmacokinetics & Pharmacodynamics
·         Organic Chemical Engineering
·         Medicinal Biochemistry
·         Computational Chemistry
·         Chemical Biology

We are privileged to have Dr.Anthony Melvin Crasto as our honourable guest.

For all the speaker’s details visit our Scientific Program

If you want to be a part of our international summit contact

Thursday, 13 September 2018

A Historic FLUORINE Discovery

Fluorine is one of the foremost crucial components of life. In its fluoride form, it is a mineral with anti-acid properties utilized in toothpaste and drinking water to prevent dental cavities. This small, non-toxic element is also broadly utilized by medicinal chemists in cancer treatment, antibiotics, anti-depressants, steroids and different drugs. Fluorine is regular in modern drugs as it stabilizes drugs and improves their biological activity.
For many years, researchers have been studying the regulation of thiols, compounds that affect a variety of biological functions in mammals including redox stress levels, energy balance, cellular signalling, coronary heart health, and autoimmune and neurological conditions. While thiol levels are stable, people are normally healthy. Once they increase too much and for too lengthy, situations including rheumatoid arthritis, breast cancer, Alzheimer's and Parkinson's diseases can develop.
Cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO) regulates the thiol levels in our body. While the thiol levels are increased, CDO and ADO develop catalytic amplifiers to quickly eliminate thiol from the body. Scientists don't yet understand exactly how the enzymes make the amplifiers.

The scientists carried out a method on CDO known as genetic code expansion.
The researchers made a new form of CDO with two exceptionally strong carbon-fluorine bonds. This need to have made it tougher for the enzyme to break those carbon-fluorine bonds and bring its catalytic amplifier. What they found, however, surprised them. They observed that the modified CDO was still capable to break its carbon-fluorine bonds to generate its full catalytic assembly.
This is the first time that scientists have confirmed the cleavage (breakage) of a carbon-fluorine bond thru oxidation in proteins. Because of this, it may be possible that human bodies are able to break these bonds in the drugs that are consumed.
Researcher’s additionally uncovered clues as to how thiols generate their catalytic amplifiers after the proteins are built.
More than 20% of
pharmaceutical drugs contain fluorine. Due to their energy, fluorine-carbon bonds resist normal drug metabolism and may extend the useful lifetime of the drug in the body. Fluorine in drug molecules can also increase their capability to cross membrane barriers and enter cells. That the carbon-fluorine is strongly safe to cleavage could be a long-held conviction in medicinal chemistry.
Pharmaceutical companies have to remind that fluorine chemistry is very complex. Even though valuable, it is highly recommended to proceed with caution, because there's still a lot to learn.
Understanding the C-F bond is important to our understanding of
drug design and enhancing the lives of patients.

Monday, 3 September 2018

ENZYMES: Key for Drug Development

Researchers are mapping the characteristic of particular enzymes which may also facilitate the development of new drugs to combat bacterial contamination, cancer and probably neurodegenerative diseases like autism, Down syndrome, Parkinson's disease and Alzheimer's.

Sulfur is one of most abundant elements in the body however little is thought approximately the enzymes concerned in its metabolism

Autistic, Alzheimer and Down syndrome patients all reveal abnormal sulfur metabolism. If we will work out how human sulfur-oxidizing enzymes function, or more crucially, how their behaviour changes in bacteria or in specific diseases, this information may be used for the rational design of drugs targeted for those diseases. Presently, no such technology exists.

Retro-engineering the sulfur oxidation method and mapping out of the chemical mechanism of 3 key enzymes—cysteine dioxygenase, cysteamine dioxygenase, and three-mercaptopropionic acid dioxygenase—to provide the necessary framework to increase effective treatments and drugs for different disease states.

By means of comparing the behaviour of these enzymes in human beings to bacteria, we also can open up possibilities to stamp out "superbugs" via offering an alternate method to disrupt bacterial metabolism without adversely affecting the patient, That is specifically important as we are now seeing widespread drug-resistant bacterial strains
Researchers use rapid-mix, freeze-quench techniques to 'trap' and monitor the progress of chemical reactions at millisecond intervals. Analysis of those consequences offers a step-by-step picture of how these enzymes function in both mammals and bacteria.

They look at fundamental life processes outside the traditional sphere of biochemistry and employs very current strategies to analyze enzyme function and regulation
By providing the fundamental scientific background had to develop treatments for important conditions and they want to make a real impact on the development of new scientific solutions

What will be the Future of Antimicrobials?

Bacterial resistant- This study may aid in preventing antibacterial resistance!! Bacteria are microscopic single-celled organisms. It...